Dorsal Cochlear Nucleus Hyperactivity and Tinnitus: Are They Related? Purpose Eight lines of evidence implicating the dorsal cochlear nucleus (DCN) as a tinnitus contributing site are reviewed. We now expand the presentation of this model, elaborate on its essential details, and provide answers to commonly asked questions regarding its validity. Conclusions Over the past decade, numerous studies ... Supplement Article
Supplement Article  |   December 01, 2008
Dorsal Cochlear Nucleus Hyperactivity and Tinnitus: Are They Related?
 
Author Affiliations & Notes
  • James A. Kaltenbach
    Cleveland Clinic Foundation, Cleveland, OH
  • Donald A. Godfrey
    University of Toledo, Toledo, OH
  • Contact author: James A. Kaltenbach, Department of Neurosciences/Otolaryngology, Cleveland Clinic Foundation, Cleveland, OH 44195. E-mail: kaltenj@ccf.org.
Article Information
Hearing Disorders / Supplement: Tinnitus
Supplement Article   |   December 01, 2008
Dorsal Cochlear Nucleus Hyperactivity and Tinnitus: Are They Related?
American Journal of Audiology, December 2008, Vol. 17, S148-S161. doi:10.1044/1059-0889(2008/08-0004)
History: Received November 17, 2007 , Accepted September 16, 2008
 
American Journal of Audiology, December 2008, Vol. 17, S148-S161. doi:10.1044/1059-0889(2008/08-0004)
History: Received November 17, 2007; Accepted September 16, 2008
Web of Science® Times Cited: 39

Purpose Eight lines of evidence implicating the dorsal cochlear nucleus (DCN) as a tinnitus contributing site are reviewed. We now expand the presentation of this model, elaborate on its essential details, and provide answers to commonly asked questions regarding its validity.

Conclusions Over the past decade, numerous studies have converged to support the hypothesis that the DCN may be an important brain center in the generation and modulation of tinnitus. Although other auditory centers have been similarly implicated, the DCN deserves special emphasis because, as a primary acoustic nucleus, it occupies a potentially pivotal position in the hierarchy of functional processes leading to the emergence of tinnitus percepts. Moreover, because a great deal is known about the underlying cellular categories and the details of synaptic circuitry within the DCN, this brain center offers a potentially powerful model for probing mechanisms underlying tinnitus.

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