Mitochondria and Risk for Deafness Although the ototoxicity of aminoglycosides has been known for more than 40 years, a convincing molecular basis for that toxicity has not been described until recently. Recent molecular and human genetic data support the notion that aminoglycoside-induced deafness is the result of mitochondrial dysfunction in the inner ear. A review ... Edge Report
Edge Report  |   March 01, 1995
Mitochondria and Risk for Deafness
 
Author Affiliations & Notes
  • Tim P. Hutchin
    University of Southern California, Los Angeles
    Institute for Toxicology, Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Ave., Los Angeles, CA 90033
  • Gino A. Cortopassi
    University of Southern California, Los Angeles
Article Information
Hearing Disorders / Edge Report
Edge Report   |   March 01, 1995
Mitochondria and Risk for Deafness
American Journal of Audiology, March 1995, Vol. 4, 12-14. doi:10.1044/1059-0889.0401.12
History: Received January 18, 1994 , Accepted June 2, 1994
 
American Journal of Audiology, March 1995, Vol. 4, 12-14. doi:10.1044/1059-0889.0401.12
History: Received January 18, 1994; Accepted June 2, 1994
Acknowledgments
We thank Barbara Cone-Wesson for helpful comments, our collaborators of the Hutchin et al. (1993)  group for providing samples, and the National Institutes of Health (AG11967-01 and CA56407-01) and the U.S. Department of Energy (F603-93R61236) for research support.
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