Outer and Middle Ear Status and Distortion Product Otoacoustic Emissions in Children With Sickle Cell Disease The purpose of this study was to investigate distortion product otoacoustic emissions (DPOAEs) and outer/middle ear status in 12 African American children with normal hearing and homozygous sickle cell disease (SCD) and age-, gender-, and ear-matched African American controls. C. R. Downs, A. Stuart, & D. Holbert (2000)  reported that ... Research Article
Research Article  |   December 01, 2004
Outer and Middle Ear Status and Distortion Product Otoacoustic Emissions in Children With Sickle Cell Disease
 
Author Affiliations & Notes
  • Letitia J. Walker
    East Carolina University, Greenville
  • Andrew Stuart, PhD
    East Carolina University, Greenville
    Department of Communication Sciences and Disorders, East Carolina University, Greenville, NC 27858-4353
  • Walter B. Green
    Dalhousie University, Halifax, Nova Scotia
  • Corresponding author: e-mail: stuarta@mail.ecu.edu
Article Information
Hearing Disorders / Special Populations / Genetic & Congenital Disorders / Research and Technology / Research Articles
Research Article   |   December 01, 2004
Outer and Middle Ear Status and Distortion Product Otoacoustic Emissions in Children With Sickle Cell Disease
American Journal of Audiology, December 2004, Vol. 13, 164-172. doi:10.1044/1059-0889(2004/021)
History: Received December 17, 2003 , Revised March 19, 2004 , Accepted April 28, 2004
 
American Journal of Audiology, December 2004, Vol. 13, 164-172. doi:10.1044/1059-0889(2004/021)
History: Received December 17, 2003; Revised March 19, 2004; Accepted April 28, 2004

The purpose of this study was to investigate distortion product otoacoustic emissions (DPOAEs) and outer/middle ear status in 12 African American children with normal hearing and homozygous sickle cell disease (SCD) and age-, gender-, and ear-matched African American controls. C. R. Downs, A. Stuart, & D. Holbert (2000)  reported that DPOAE amplitudes were significantly larger for children with SCD. Because the integrity of the middle ear system directly influences OAE characteristics, it was felt that concurrent investigation of DPOAE amplitudes and outer/middle ear function in children with SCD was warranted. DPOAEs were evoked by 13 primary-tone pairs with f2 frequencies ranging from 1000 to 4500 Hz. Outer/middle ear status was assessed with tympanometry through indices of peak compensated static acoustic admittance, tympanometric width, tympanometric peak pressure, ear canal volume, and middle ear resonance frequency. Tympanograms were recorded with probe-tone frequencies of 226 and 678 Hz. DPOAE amplitudes were significantly larger for children with SCD (p < .05). There were no group differences in any of the middle ear indices (p > .05). These findings suggest that increased DPOAE amplitudes for children with SCD cannot be attributed to differences in outer/middle ear function as assessed with tympanometry.

Acknowledgments
Special thanks to the Sickle Cell Clinic at the East Carolina University School of Medicine, particularly Dr. Charles Daeschner and Dianna Gordon for their assistance with this project. Appreciation is extended to Drs. C. Shera and S. Puria for their valuable insights and suggestions. Also, thanks to Ms. Renée Downs for her input and to Mr. Mark Allen for technical assistance.
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