Familial Aggregation of Age-Related Hearing Loss in an Epidemiological Study of Older Adults Purpose: To estimate the genetic contributions to presbycusis.Method: Presbycusis was assessed by audiometric measurements at 3 waves of the population-based Epidemiology of Hearing Loss Study (EHLS). Measurements from the most recent hearing examination were used, at which time the subjects (3,510 participants from the EHLS study) were between ... Article
Article  |   December 2009
Familial Aggregation of Age-Related Hearing Loss in an Epidemiological Study of Older Adults
 
Author Affiliations & Notes
  • Laura A. Raynor
    University of Minnesota, Minneapolis
  • James S. Pankow
    University of Minnesota, Minneapolis
  • Michael B. Miller
    University of Minnesota, Minneapolis
  • Guan-Hua Huang
    National Chiao Tung University, Hsinchu, Taiwan
  • Dayna Dalton
    University of Wisconsin—Madison
  • Ronald Klein
    University of Wisconsin—Madison
  • Barbara E. K. Klein
    University of Wisconsin—Madison
  • Karen J. Cruickshanks
    University of Wisconsin—Madison
  • Contact author: Laura Raynor, University of Minnesota, Division of Epidemiology & Community Health, 1300 S. Second Street, Suite 300, Minneapolis, MN 55454-1015. E-mail: rayno007@umn.edu.
  • © 2009 American Speech-Language-Hearing AssociationAmerican Speech-Language-Hearing Association
Article Information
Hearing Disorders / Special Populations / Older Adults & Aging
Article   |   December 2009
Familial Aggregation of Age-Related Hearing Loss in an Epidemiological Study of Older Adults
American Journal of Audiology, December 2009, Vol. 18, 114-118. doi:10.1044/1059-0889(2009/08-0035)
History: Received November 12, 2008 , Accepted April 27, 2009
 
American Journal of Audiology, December 2009, Vol. 18, 114-118. doi:10.1044/1059-0889(2009/08-0035)
History: Received November 12, 2008; Accepted April 27, 2009
Web of Science® Times Cited: 8

Purpose: To estimate the genetic contributions to presbycusis.

Method: Presbycusis was assessed by audiometric measurements at 3 waves of the population-based Epidemiology of Hearing Loss Study (EHLS). Measurements from the most recent hearing examination were used, at which time the subjects (3,510 participants from the EHLS study) were between 48 and 100 years of age. Heritability of presbycusis was estimated using maximum likelihood methods in 973 biological relative pairs from 376 families. Familial aggregation was also evaluated by tetrachoric correlations, odds ratios, and lambda statistics in 594 sibling pairs from 373 sibships.

Results: The prevalence of presbycusis conformed to previous research, increasing with age and male sex. Heritability estimates for presbycusis adjusted for age, sex, education level, and exposure to work noise exceeded 50%, and siblings of an affected relative were at 30% higher risk. When stratified by sex, estimates of familial aggregation were higher in women than men.

Conclusions: There is evidence that genetic factors contribute to age-related hearing loss in this population-based sample. The familial aggregation is stronger in women than in men.

Acknowledgments
This research was supported by National Institutes of Health Grants AG021917 (Cruickshanks) and AG11099 (Cruickshanks).
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