Higher Prevalence of Autoimmune Diseases and Longer Spells of Vertigo in Patients Affected With Familial Ménière's Disease: A Clinical Comparison of Familial and Sporadic Ménière's Disease Purpose This study compared clinical features, predisposing factors, and concomitant diseases between sporadic and familial Ménière's disease (MD). Method Retrospective chart review and postal questionnaire were used. Participants were 250 definite patients with MD (sporadic, n =149; familial, n = 101) who fulfilled the American Academy of Otorhinolaryngology–Head ... Research Note
Research Note  |   June 01, 2014
Higher Prevalence of Autoimmune Diseases and Longer Spells of Vertigo in Patients Affected With Familial Ménière's Disease: A Clinical Comparison of Familial and Sporadic Ménière's Disease
 
Author Affiliations & Notes
  • Elina Hietikko
    Institute of Biomedicine, University of Oulu, Oulu, Finland
    Oulu University Hospital, Oulu, Finland
  • Martti Sorri
    Oulu University Hospital, Oulu, Finland
  • Minna Männikkö
    Institute of Biomedicine, University of Oulu, Oulu, Finland
    Institute of Health Sciences, University of Oulu, Oulu, Finland
  • Jouko Kotimäki
    Central Hospital of Kainuu, Kajaani, Finland
  • Disclosure: The authors have declared that no competing interests existed at the time of publication.
    Disclosure: The authors have declared that no competing interests existed at the time of publication.×
  • Correspondence to Elina Hietikko: elina.hietikko@oulu.fi
  • Editor: Larry Humes
    Editor: Larry Humes×
Article Information
Hearing Disorders / Balance & Balance Disorders / Research Notes
Research Note   |   June 01, 2014
Higher Prevalence of Autoimmune Diseases and Longer Spells of Vertigo in Patients Affected With Familial Ménière's Disease: A Clinical Comparison of Familial and Sporadic Ménière's Disease
American Journal of Audiology, June 2014, Vol. 23, 232-237. doi:10.1044/2014_AJA-13-0060
History: Received October 25, 2013 , Revised February 13, 2014 , Accepted February 21, 2014
 
American Journal of Audiology, June 2014, Vol. 23, 232-237. doi:10.1044/2014_AJA-13-0060
History: Received October 25, 2013; Revised February 13, 2014; Accepted February 21, 2014
Web of Science® Times Cited: 3

Purpose This study compared clinical features, predisposing factors, and concomitant diseases between sporadic and familial Ménière's disease (MD).

Method Retrospective chart review and postal questionnaire were used. Participants were 250 definite patients with MD (sporadic, n =149; familial, n = 101) who fulfilled the American Academy of Otorhinolaryngology–Head and Neck Surgery (1995)  criteria.

Results On average, familial patients were affected 5.6 years earlier than sporadic patients, and they suffered from significantly longer spells of vertigo (p = .007). The prevalence of rheumatoid arthritis (p = .002) and other autoimmune diseases (p = .046) was higher among the familial patients, who also had more migraine (p = .036) and hearing impairment (p = .002) in their families.

Conclusion The clinical features of familial and sporadic MD are very similar in general, but some differences do exist. Familial MD patients are affected earlier and suffer from longer spells of vertigo.

Acknowledgments
This work was supported by the Emil Aaltonen Foundation, the Finnish Foundation for Ear Diseases, and the Finnish Medical Foundation. We would like to thank all the patients for their active participation in the study.
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