Auditory Middle Latency Responses Differ in Right- and Left-Handed Subjects: An Evaluation Through Topographic Brain Mapping Purpose To investigate the association of handedness with auditory middle latency responses (AMLRs) using topographic brain mapping by comparing amplitudes and latencies in frontocentral and hemispheric regions of interest (ROIs). Method The study included 44 healthy subjects with normal hearing (22 left handed and 22 right handed). AMLRs ... Research Article
Research Article  |   September 01, 2014
Auditory Middle Latency Responses Differ in Right- and Left-Handed Subjects: An Evaluation Through Topographic Brain Mapping
 
Author Affiliations & Notes
  • Mehrnaz Mohebbi
    Iran University of Medical Sciences, Tehran, Iran
    Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Saeid Mahmoudian
    Iran University of Medical Sciences, Tehran, Iran
    Medical University of Hannover, Hannover, Germany
  • Marzieh Sharifian Alborzi
    Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mojtaba Najafi-Koopaie
    Shahed University, Tehran, Iran
  • Ehsan Darestani Farahani
    Amirkabir University of Technology, Tehran, Iran
  • Mohammad Farhadi
    Iran University of Medical Sciences, Tehran, Iran
  • Disclosure: The authors have declared that no competing interests existed at the time of publication.
    Disclosure: The authors have declared that no competing interests existed at the time of publication.×
  • Correspondence to Saeid Mahmoudian: mahmoudian.s@iums.ac.ir or mahmoudian.saeid@mh-hannover.de
  • Editor: Larry Humes
    Editor: Larry Humes×
Article Information
Hearing & Speech Perception / Hearing Disorders / Research Articles
Research Article   |   September 01, 2014
Auditory Middle Latency Responses Differ in Right- and Left-Handed Subjects: An Evaluation Through Topographic Brain Mapping
American Journal of Audiology, September 2014, Vol. 23, 273-281. doi:10.1044/2014_AJA-13-0059
History: Received October 23, 2013 , Revised December 24, 2013 , Accepted April 13, 2014
 
American Journal of Audiology, September 2014, Vol. 23, 273-281. doi:10.1044/2014_AJA-13-0059
History: Received October 23, 2013; Revised December 24, 2013; Accepted April 13, 2014
Web of Science® Times Cited: 2

Purpose To investigate the association of handedness with auditory middle latency responses (AMLRs) using topographic brain mapping by comparing amplitudes and latencies in frontocentral and hemispheric regions of interest (ROIs).

Method The study included 44 healthy subjects with normal hearing (22 left handed and 22 right handed). AMLRs were recorded from 29 scalp electrodes in response to binaural 4-kHz tone bursts.

Results Frontocentral ROI comparisons revealed that Pa and Pb amplitudes were significantly larger in the left-handed than the right-handed group. Topographic brain maps showed different distributions in AMLR components between the two groups. In hemispheric comparisons, Pa amplitude differed significantly across groups. A left-hemisphere emphasis of Pa was found in the right-handed group but not in the left-handed group.

Conclusion This study provides evidence that handedness is associated with AMLR components in frontocentral and hemispheric ROI. Handedness should be considered an essential factor in the clinical or experimental use of AMLRs.

Acknowledgments
This study was supported by the ENT and Head & Neck Research Center (MT/9053/1391.03.30), Iran University of Medical Sciences.
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