Functional Connectivity in Patients With Sensorineural Hearing Loss Using Resting-State MRI Purpose This study was undertaken to evaluate whole-brain functional connectivity changes related to auditory cortex in patients with left-sided sensorineural hearing loss (SNHL) using resting-state functional connectivity magnetic resonance imaging. Method Imaging was performed in 19 patients with left-sided SNHL and 35 individuals in the control group without ... Research Article
Research Article  |   June 01, 2015
Functional Connectivity in Patients With Sensorineural Hearing Loss Using Resting-State MRI
 
Author Affiliations & Notes
  • Bin Liu
    Zhong-Da Hospital, Southeast University, Nanjing, China
  • Yuan Feng
    Zhong-Da Hospital, Southeast University, Nanjing, China
  • Ming Yang
    Zhong-Da Hospital, Southeast University, Nanjing, China
  • Jing-ya Chen
    Zhong-Da Hospital, Southeast University, Nanjing, China
  • Jing Li
    Zhong-Da Hospital, Southeast University, Nanjing, China
  • Zhi-chun Huang
    Zhong-Da Hospital, Southeast University, Nanjing, China
  • Ling-ling Zhang
    Zhong-Da Hospital, Southeast University, Nanjing, China
  • Disclosure: The authors have declared that no competing interests existed at the time of publication.
    Disclosure: The authors have declared that no competing interests existed at the time of publication.×
  • Yuan Feng and Bin Liu contributed equally to this article.
    Yuan Feng and Bin Liu contributed equally to this article.×
  • Correspondence to Bin Liu: liubin1220@126.com
  • Editor and Associate Editor: Larry Humes
    Editor and Associate Editor: Larry Humes×
Article Information
Hearing Disorders / Research Articles
Research Article   |   June 01, 2015
Functional Connectivity in Patients With Sensorineural Hearing Loss Using Resting-State MRI
American Journal of Audiology, June 2015, Vol. 24, 145-152. doi:10.1044/2015_AJA-13-0068
History: Received December 25, 2013 , Revised April 22, 2014 , Accepted January 11, 2015
 
American Journal of Audiology, June 2015, Vol. 24, 145-152. doi:10.1044/2015_AJA-13-0068
History: Received December 25, 2013; Revised April 22, 2014; Accepted January 11, 2015
Web of Science® Times Cited: 1

Purpose This study was undertaken to evaluate whole-brain functional connectivity changes related to auditory cortex in patients with left-sided sensorineural hearing loss (SNHL) using resting-state functional connectivity magnetic resonance imaging.

Method Imaging was performed in 19 patients with left-sided SNHL and 35 individuals in the control group without SNHL. Data were collected and analyzed to map functional connectivity using the left/right primary auditory cortex as the region of interest to identify global differences between patients with SNHL and the control group.

Results In comparison to the control group, the SNHL group was found to have significant functional connectivity changes in the auditory system, recognition network, visual cortex, and language network.

Conclusion These findings suggest that functional brain alterations in unilateral SNHL patients may indicate reorganizations that occur in response to auditory deficits.

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