Efficiency of Melatonin as Compared to Pentobarbital for Audiometry Brainstem Response in Children With Associated Disorders Purpose Outpatient pediatric audiometry brainstem response (ABR) uses various techniques (no drug, hydroxyzine, pentobarbital, melatonin). The aim of this study was to evaluate the efficiency of melatonin as compared to pentobarbital in children with associated disorders. Method This was a retrospective study that took place in a tertiary ... Research Article
Research Article  |   September 01, 2016
Efficiency of Melatonin as Compared to Pentobarbital for Audiometry Brainstem Response in Children With Associated Disorders
 
Author Affiliations & Notes
  • Joanne Guerlain
    Service d'Oto-Rhino-Laryngologie Pédiatrique, Hôpital Necker Enfants Malades, Paris, France
  • Antoine Paul
    Service d'Oto-Rhino-Laryngologie Pédiatrique, Hôpital Necker Enfants Malades, Paris, France
  • Isabelle Rouillon
    Service d'Oto-Rhino-Laryngologie Pédiatrique, Hôpital Necker Enfants Malades, Paris, France
  • Marine Parodi
    Service d'Oto-Rhino-Laryngologie Pédiatrique, Hôpital Necker Enfants Malades, Paris, France
  • Erea Noel Garabedian
    Service d'Oto-Rhino-Laryngologie Pédiatrique, Hôpital Necker Enfants Malades, Paris, France
  • Natalie Loundon
    Service d'Oto-Rhino-Laryngologie Pédiatrique, Hôpital Necker Enfants Malades, Paris, France
  • Disclosure: The authors have declared that no competing interests existed at the time of publication.
    Disclosure: The authors have declared that no competing interests existed at the time of publication. ×
  • Correspondence to Joanne Guerlain: joanne.guerlain@gmail.com
  • Editor: Sumitrajit Dhar
    Editor: Sumitrajit Dhar×
  • Associate Editor: Ann Eddins
    Associate Editor: Ann Eddins×
Article Information
Hearing Disorders / Research Articles
Research Article   |   September 01, 2016
Efficiency of Melatonin as Compared to Pentobarbital for Audiometry Brainstem Response in Children With Associated Disorders
American Journal of Audiology, September 2016, Vol. 25, 206-210. doi:10.1044/2016_AJA-15-0075
History: Received November 27, 2015 , Revised February 28, 2016 , Accepted April 30, 2016
 
American Journal of Audiology, September 2016, Vol. 25, 206-210. doi:10.1044/2016_AJA-15-0075
History: Received November 27, 2015; Revised February 28, 2016; Accepted April 30, 2016

Purpose Outpatient pediatric audiometry brainstem response (ABR) uses various techniques (no drug, hydroxyzine, pentobarbital, melatonin). The aim of this study was to evaluate the efficiency of melatonin as compared to pentobarbital in children with associated disorders.

Method This was a retrospective study that took place in a tertiary care center. Eighty-three children (34 girls and 49 boys) had performed ABR under pentobarbital (GPent) or melatonin (GMel) between 2013 and 2014 and were included. All children had associated neurological or behavioral disorders or had failed a previous ABR using another technique. Success rate, defined as completed binaural investigation, delay, and duration of sleep (minutes), as well as side effects, were compared between GPent and GMel.

Results There were 56 patients in GMel and 27 in GPent, with a mean age at test of 3 years and 10 months (1–13 years) and 4 years and 1 month (1–14.5 years), respectively. Success rate was 76.8% and 88.8%, respectively (p > .05), sleep duration was 23 and 153 min (p < .0001), and mean delay was 35 and 54 min. No side effects have been reported.

Conclusions Melatonin is a drug widely used, particularly for electroencephalogram in children. Sleep duration allowed a success rate that was comparable to pentobarbital. Melatonin seems to be an efficient alternative to pentobarbital for pediatric ABR.

Acknowledgments
There are no financial interests, relationships, or affiliations relevant to the subject of the article. The authors have stated that they have no interests and no source of funding that might be perceived as posing a conflict or bias.
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